Research Activities
The Department of Pharmaceutical Sciences was established in 1995 at Guru Nanak Dev University, Amritsar with a clear vision to produce trained professionals to meet the ever-growing demand in Pharmaceutical Industry and Academia. The Department is recognized by Pharmacy Council of India (PCI) and All India Council of Technical Education (AICTE), New Delhi. The department is enriched with highly qualified faculty and is presently running Bachelor of Pharmacy and Masters of Pharmacy courses in Pharmaceutics, Pharmaceutical chemistry, Pharmacology, Pharmacognosy and Ph.D course in all disciplines. The department is well equipped with state of the art laboratories in Pharmaceutics, Pharmaceutical chemistry, Pharmacology and Pharmacognosy sections. The infrastructure available makes the department a conducive place for academic learning that provides students with quality education in a clean and comfortable environment. In last few years, more than 200 research papers have been published and presented at various national and international conference chairs. Under the chairmanship of Prof. (Dr.).Preet Mohinder Singh Bedi, the department is working towards becoming a center of excellence in Pharmaceutical Education and Research. The department has research collaborations with various national and international institutes. Number of research projects in the department has been funded by various scientific agencies including CSIR, DST, UGC, and AICTE. The department has very good placement record with students holding jobs in government sector, Academics and in industry as R & D scientists.
Major Research Area
Presently, the department is engaged in following major Research area:
Anti-cancer medicinal chemistry
The term "cancer" refers to a group of diseases that involve abnormal cell growth with the potential to spread to other parts of the body. As each cancer consists of a variety of different cell types highly effective at developing resistance to both drug and radiation therapy, it is a particularly difficult disease to treat. The challenge for the field of medicinal chemistry is to design drugs capable of selectively targeting cancer cells while avoiding multidrug resistance pathways. Using recent insights into the unique attributes of cancer cells, Medicinal Chemistry is pursuing anti-tumour agents of high specificity to help design suitably targeted, selective chemotherapeutics. Current programs involve a diverse array of anti-cancer targets, such as lipid and protein kinases, microtubules, topoisomerases, hypoxia inducible factors, bromodomains and histone acetyltransferases.
Drug discovery approaches include:
- optimisation of screening hits using structure-activity relationship-guided and in silico techniques
- synthesis and optimisation of anticancer natural products
- bioconjugation of active agents to cancer seeking biomolecules
These approaches are complemented by research into new synthetic methods for expediting lead optimisation, drug-biomolecule conjugation and asymmetric natural product synthesis. These programs are undertaken in collaboration with NIPER, Mohali. Medicinal Chemistry's anti-cancer drug research is supported by the CSIR, New Delhi
The world is facing an enormous and growing threat from the emergence of superbugs that are resistant to most currently available antibiotics. Medicinal Chemistry researchers are collaborating on multiple programs to discover the next generation of antibiotic agents.
Chemical biology
Chemical biology is an exciting and rapidly evolving field of research that involves the application of synthetic chemical techniques and tools to the study and manipulation of biological systems. It is highly interdisciplinary in nature, incorporating elements from biochemistry, molecular biology, structural biology, pharmacology, drug discovery and genetics; but synthetic chemistry is key. Chemical biology seeks to unravel the causes of diseases and identify crucial biological targets for disease treatment and prevention. Chemical biologists also apply chemical principles to the modification of native biological molecules to create new function. Researchers in this area are therefore heavily involved in the development of new medical diagnostic agents, drug delivery systems and screening assays.
Pharmaceutics
- Pharmaceutics Dermaceticals, Targeted delivery of anti-HIV, anti-cancer drugs Modified Release Oral Dosage forms Bio-safety testing Development of spray drying based Pharmaceuticals Cell line and Pre-clinical study.
- Solving the problems of poor solubility and bioavailability of drugs using carrier approach such as Nanoemulsion, Microemulsion, Liposomes is in progress.
Pharmacology
- Neuropharmacology, explore learning and memory mechanisms, diabetic nephropathy
- Novel target sites and therapies for obesity, cardiac and renal failure, reno-protective agents against ischemia reperfusion injury in rats.
Pharmacognosy
- Isolation, Characterization and Pharmacological screening of natural products and herbal formulations for biologically active molecules.
Significant Contribution of Department in research (Last Five Years)
PUBLICATIONS
In SCI Journals (as per Scopus database) : 154
Impact factor (Max.) : 6.259
Cumulative Impact factor : 284
Average impact factor of top 10 articles : 3.25
Impact factor range : 0.31- 6.259
Citations in last five years : 1425
h-Index (as per Scopus database) : 22
I10 Index : 53
No. of Patents Applied : 04
Book chapters : 06
Research projects sanctioned : 09
Total Grant received : 124.3 Lac
Research collaborations/MOU : 06
Awards/Recognition to Faculty members : 07
Awards to PG/Research students in conferences : 13
No. of Ph.D. Awarded In last five years : 20
No. of Ph.D. Thesis submitted : 06
No. of students qualified GPAT examination : 80
Invited lectures/Chairmanships : 30
Conferences attended (India) : 80
Conferences attended (International) : 02